Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc9.6 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Immunohistochemical analysis of somatostatin receptor 2 and the tumor microenvironment in a large set of pheochromocytomas and paragangliomas

Uchihara Masaki , Tanabe Akiyo , Umamoto Kotaro , Maeshima Akiko Miyagi , Kojima Yuki , Sudo Kazuki , Shimoi Tatsunori , Yamazaki Yuto , Sasano Hironobu , Shimomura Akihiko , Shimizu Chikako , Yonemori Kan , Kajio Hiroshi

Introduction: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumors with few effective treatment options for malignant cases. Novel therapeutic indications, such as 177Lu-DOTA-TATE and immune checkpoint inhibitors (ICIs) for patients with PPGL, have been investigated in several clinical trials. Emerging evidence shows that somatostatin receptor 2 (SSTR2) in other cancer types correlates with the tumor microenvironment (TME) activation and could be a predictive bi...